10 Supportive Supplements for GLP-1 Therapies

Nearly everyone has heard of GLP-1 medications, such as semaglutide (Ozempic ®). They have become increasingly popular for managing type 2 diabetes and obesity by mimicking the GLP-1 hormone, which helps regulate blood sugar levels, promote satiety, and reduce appetite. As effective as these medications are, many people look for additional support through the use of supplements to optimize their overall health and enhance the effects of GLP-1 treatments. Let’s check out various supplement options that may be helpful to take alongside GLP-1 medications. If you yourself are taking GLP-1 therapies, make sure to consult your medical provider before beginning a new regime.

Supplements to Consider

1. Probiotics: The gut microbiome plays a crucial role in metabolism and weight management (1). Certain probiotic strains, such as Lactobacillus and Bifidobacterium, may enhance gut health, support digestion, and potentially improve the efficacy of GLP-1 medications by optimizing gut-brain communication.

2. Omega-3 Fatty Acids: Found in fish oil and flaxseeds, omega-3 fatty acids have anti-inflammatory properties (2) that can support cardiovascular health, a key concern for individuals with type 2 diabetes. Omega-3s may also help improve insulin sensitivity and support weight management efforts alongside GLP-1 therapy.

3. Berberine: This plant compound has been shown to help regulate blood sugar levels and improve insulin sensitivity (3). Berberine works with GLP-1 medications by targeting similar metabolic pathways, potentially enhancing their effects and providing additional glycemic control.

4. Magnesium: An essential mineral involved in hundreds of biochemical reactions, magnesium supports insulin function and glucose metabolism (4). Many individuals are deficient in magnesium, and supplementation can help improve blood sugar control and reduce the risk of cardiovascular complications.

5. Chromium: This trace mineral is known for its role in enhancing insulin action and glucose metabolism (5). Chromium supplements may aid in better blood sugar management, complementing the action of GLP-1 medications.

6. Fiber Supplements: Soluble fiber supplements, such as psyllium husk or glucomannan, can promote feelings of fullness, aid in weight management, and help maintain steady blood sugar levels (6). They can be a helpful addition for individuals looking to enhance satiety and support their GLP-1 therapy.

7. Protein Powder: Incorporating a high-quality protein powder can support muscle maintenance and growth (7), particularly during weight loss. Adequate protein intake is essential for preserving lean muscle mass and supporting metabolic health.

8. B Vitamins: B vitamins, especially B12, B6, and folate, play a critical role in energy metabolism and the proper functioning of the nervous system (8). Supplementation can help individuals maintain energy levels and overall well-being while on GLP-1 therapy.

9. Zinc: This essential mineral supports immune function, wound healing, and insulin action (9). Zinc supplementation may help optimize metabolic health and support the effects of GLP-1 medications.

10. Creatine: Known primarily for its benefits in athletic performance, creatine can also support muscle health and energy metabolism (10). It may help preserve muscle mass during weight loss and provide additional energy support for those engaging in physical activity -which should be a part of your GLP-1 journey.

How Brands Can Help

The rise of GLP-1 medications gives us some insight into what supplements could become more in demand as a result. This offers an opportunity for brands to support the increase of GLP-1 users by developing products that complement these therapies and enhance their effectiveness. As more people turn to GLP-1 medications for diabetes, weight management, and overall health optimization, brands that are ready with high-quality supplements to help them achieve their health goals can benefit. By working with Factory6, brands have access to a true partner who is transforming the manufacturing experience. Our commitment to exceptional customer service and creative product formulations sets our clients on the road to success. 

1. Probiotics for the Treatment of Overweight and Obesity in Humans—A Review of Clinical Trials - PMC (nih.gov)

2. Omega-3 Fatty Acids And Inflammation – You Are What You Eat! - PMC (nih.gov)

3. Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials - PMC (nih.gov)

4. The Effects of Oral Magnesium Supplementation on Glycemic Response among Type 2 Diabetes Patients - PMC (nih.gov)

5. A scientific review: the role of chromium in insulin resistance - PubMed (nih.gov)

6. The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives - PMC (nih.gov)

7. The effects of protein supplements on muscle mass, strength, and aerobic and anaerobic power in healthy adults: a systematic review - PubMed (nih.gov)

8. B Vitamins: Functions and Uses in Medicine - PMC (nih.gov)

9. Zinc supplementation improves glycemic control for diabetes prevention and management: a systematic review and meta-analysis of randomized controlled trials - PubMed (nih.gov)

10. Creatine Supplementation for Muscle Growth: A Scoping Review of Randomized Clinical Trials from 2012 to 2021 - PMC (nih.gov)